Injectable Wrinkle relaxers are among the most researched and widely used nonsurgical medical aesthetic procedures for dynamic facial lines. Understanding the differences between Botox, Dysport, Jeuveau, Xeomin, and Daxxify is essential for making informed decisions about injectable wrinkle treatments.
What Are Wrinkle Relaxers?
Wrinkle relaxers, also known as neuromodulators, are injectable medications that temporarily reduce muscle activity responsible for dynamic facial wrinkles. All five FDA-approved products—Botox, Dysport, Jeuveau, Xeomin, and Daxxify—contain botulinum toxin type A, but differ in formulation, onset, duration, and clinical data.
Botox (OnabotulinumtoxinA)
Botox is the most established neuromodulator, FDA-approved for cosmetic use since 2002. It works by inhibiting acetylcholine release at neuromuscular junctions, resulting in temporary muscle relaxation and smoothing of dynamic wrinkles, such as frown lines, forehead lines, and crow’s feet.
- FDA Approval: 2002 for glabellar lines; multiple additional indications since (FDA label)
- Mechanism: Blocks acetylcholine release, reducing muscle contraction (Medscape Overview)
- Onset: 3–7 days
- Duration: 3–4 months (individual results may vary)
- Clinical Data: Extensive research supports efficacy for facial lines, migraines, hyperhidrosis, and more (2025 study; 2023 review)
- Safety: Well-established safety profile; low complication rates (AAFP review)
Dysport (AbobotulinumtoxinA)
Dysport is FDA-approved for glabellar lines and is known for its diffusion characteristics, which may be preferred for larger treatment areas.
- FDA Approval: 2009 for glabellar lines (FDA label)
- Mechanism: Similar to Botox, blocks acetylcholine release
- Onset: 2–5 days (often slightly faster than Botox)
- Duration: 3–4 months (individual results may vary)
- Clinical Data: Demonstrated efficacy in both aesthetic and neurological indications (2025 trial; 2020 review)
- Safety: Comparable to other neuromodulators; low rates of secondary resistance (2025 meta-analysis)
Jeuveau (PrabotulinumtoxinA)
Jeuveau is the newest neuromodulator specifically developed for aesthetic use, FDA-approved in 2019 for glabellar lines.
- FDA Approval: 2019 for glabellar lines (FDA label)
- Mechanism: Acetylcholine release inhibitor, similar to Botox
- Onset: 2–5 days
- Duration: 3–4 months (some studies report up to 6 months; individual results may vary)
- Clinical Data: High patient satisfaction and efficacy in phase III and real-world studies (2019 pivotal trial; 2024 study)
- Safety: Comparable to other botulinum toxins; rare risk of swallowing or breathing difficulties (FDA label)
Xeomin (IncobotulinumtoxinA)
Xeomin is a “naked” form of botulinum toxin A, free from accessory proteins. This may reduce the risk of antibody formation over time.
- FDA Approval: 2011 for glabellar lines (FDA label)
- Mechanism: Pure 150-kDa neurotoxin, blocks acetylcholine release
- Onset: 3–7 days
- Duration: 3–4 months (individual results may vary)
- Clinical Data: Effective for dynamic wrinkles and neurological conditions; low immunogenicity (2024 review; 2022 safety study)
- Safety: Well-tolerated; low risk of antibody development
Daxxify (DaxibotulinumtoxinA)
Daxxify is the newest FDA-approved neuromodulator, notable for its proprietary peptide technology and extended duration of effect.
- FDA Approval: 2022 for glabellar lines (FDA Drug Snapshot)
- Mechanism: Botulinum toxin A with a novel peptide excipient for longer duration (2021 study)
- Onset: 1–2 days (some patients)
- Duration: 4–6 months (up to 6 months in pivotal trials; individual results may vary)
- Clinical Data: Demonstrated efficacy and safety in multiple phase III trials (2021 pivotal trial; 2023 data)
- Safety: Lower adverse reaction rates at approved doses (2024 review)
Comparison Table: Wrinkle Relaxers at a Glance
| Product | FDA Approval | Onset | Duration | Unique Feature | Key Indications |
|---|---|---|---|---|---|
| Botox | 2002 | 3–7 days | 3–4 months | Most studied, broadest use | Glabellar, forehead, crow’s feet, migraines, hyperhidrosis |
| Dysport | 2009 | 2–5 days | 3–4 months | Diffuses more, covers larger areas | Glabellar lines, spasticity, dystonia |
| Jeuveau | 2019 | 2–5 days | 3–4 months (up to 6) | Aesthetic-only, modern manufacturing | Glabellar lines |
| Xeomin | 2011 | 3–7 days | 3–4 months | No accessory proteins | Glabellar lines, dystonia, spasticity |
| Daxxify | 2022 | 1–2 days | 4–6 months | Longest duration, peptide technology | Glabellar lines, cervical dystonia |
*Individual results may vary. Duration and onset are averages from clinical trials and real-world studies.
How to Choose the Right Wrinkle Relaxer
Selecting the most appropriate neuromodulator depends on your unique anatomy, treatment goals, and medical history. Factors such as desired onset, duration, treatment area, and previous response to botulinum toxin products should be discussed with a certified expert injector.
At Cosmetic Injectables Center Medspa, all wrinkle relaxer treatments are performed by certified expert injectors under the full-time supervision of Dr. Sherly Soleiman, MD, a nationally recognized authority in nonsurgical medical aesthetics.
Related Services and Treatment Areas
- Wrinkle Relaxers
- Botox for Migraines
- Botox for TMJ
- Botox for Underarm Sweating
- Lip Flip
- Face Treatment Areas
- Forehead & Temples
- Eyes and Under Eyes
- Jawline
- Lips
Why Choose Cosmetic Injectables Center Medspa
Cosmetic Injectables Center Medspa is a physician-led, nationally recognized practice specializing in nonsurgical medical aesthetic procedures. Dr. Sherly Soleiman, MD, a board-certified physician with over 25 years of experience and 16 years in aesthetic medicine, leads a team of certified expert injectors. As a national trainer for Allergan and a key opinion leader for top industry companies, Dr. Soleiman ensures the highest standards of safety, precision, and natural results.
- Top 1% Allergan Practice in the USA
- Full-time, on-site physician supervision
- Certified expert injectors and advanced safety protocols
- Complimentary consultations with Master Nurse Injectors
- Comprehensive, patient-first approach to facial rejuvenation
Learn more about Dr. Soleiman’s credentials:
Frequently Asked Questions
What is the difference between Botox, Dysport, Jeuveau, Xeomin, and Daxxify?
All five are FDA-approved botulinum toxin type A products for dynamic wrinkle reduction. They differ in formulation, onset, duration, and diffusion characteristics. Daxxify is notable for its longer duration, while Xeomin is free of accessory proteins.
How long do wrinkle relaxer results last?
Results typically last 3–4 months for Botox, Dysport, Jeuveau, and Xeomin. Daxxify may last 4–6 months. Individual results may vary.
Are wrinkle relaxers safe?
When administered by certified expert injectors, wrinkle relaxers have a well-established safety profile. Adverse effects are rare and typically mild. All products are FDA-approved for cosmetic use.
How soon will I see results?
Onset varies: Dysport and Jeuveau may show effects in 2–5 days, Botox and Xeomin in 3–7 days, and Daxxify as early as 1–2 days for some patients.
Can wrinkle relaxers be used for medical conditions?
Yes. Botulinum toxin products are FDA-approved for several medical indications, including migraines, TMJ, hyperhidrosis, and spasticity. See Botox for Migraines and Botox for TMJ.
Who is a candidate for wrinkle relaxers?
Most healthy adults seeking temporary reduction of dynamic facial lines are candidates. A consultation with a certified expert injector is required to determine suitability.
What are the possible side effects?
Common side effects include mild swelling, bruising, or redness at the injection site. Rare but serious risks include eyelid drooping or allergic reaction. All risks are discussed during consultation.
How do I choose the best product for me?
Product selection depends on your anatomy, goals, and previous experience. Your certified injector will recommend the most appropriate option during your consultation.
Are results reversible?
Results are temporary. If undesired effects occur, they gradually resolve as the product wears off.
How do I schedule a consultation?
Contact Cosmetic Injectables Center Medspa to schedule a complimentary consultation with a Master Nurse Injector or a physician consultation with Dr. Sherly Soleiman, MD.
For more information on wrinkle relaxers and related procedures, visit our Wrinkle Relaxers page or explore our full list of services.