Demand for regenerative skin treatments is rising as patients seek scientifically advanced, non-surgical options for skin rejuvenation. Platelet-rich plasma (PRP) and exosome therapies are at the forefront, offering new possibilities for skin repair, anti-aging, and overall skin health.
What Are PRP and Exosomes?
Platelet-rich plasma (PRP) is a concentration of platelets derived from a patient’s own blood, containing growth factors and cytokines that promote tissue repair and regeneration. Exosomes are extracellular vesicles released by cells—including platelets—that carry proteins, lipids, and genetic material, facilitating intercellular communication and tissue healing.
At Cosmetic Injectables Center Medspa, PRP and exosome therapies are offered as advanced, physician-supervised medical aesthetic procedures for skin rejuvenation and repair.
Scientific Evidence: PRP and Exosomes in Skin Rejuvenation
Recent peer-reviewed studies demonstrate the therapeutic potential of PRP-derived exosomes (PRP-Exos) in skin and tissue regeneration:
- Wound Healing and Inflammation: PRP-Exos accelerate wound closure, promote angiogenesis, and shift macrophage polarization toward anti-inflammatory phenotypes, leading to improved healing in diabetic ulcers and chronic wounds (Clinical and Experimental Medicine, 2025; Theranostics, 2017).
- Synovial and Joint Health: PRP-Exos reduce synovial inflammation and pain by enhancing lymphatic function and modulating immune responses (Journal of Nanobiotechnology, 2025; Journal of Controlled Release, 2025).
- Cellular Regeneration: PRP-Exos contain growth factors (e.g., VEGF, TGF-β, PDGF-BB) that stimulate fibroblast and endothelial cell proliferation, migration, and collagen synthesis, supporting skin rejuvenation (Journal of Cosmetic Dermatology, 2025; International Journal of Molecular Sciences, 2021).
While most studies are preclinical or early-stage clinical trials, the evidence supports PRP and exosomes as promising modalities for regenerative skin treatments.
How PRP and Exosomes Work: Mechanisms of Action
- PRP: When injected or applied to the skin, PRP releases growth factors that activate local cells, stimulate collagen production, and accelerate tissue repair.
- Exosomes: Exosomes act as biological messengers, delivering proteins, mRNA, and microRNA to recipient cells. This enhances cell proliferation, migration, angiogenesis, and modulates inflammation, all critical for skin regeneration.
PRP-derived exosomes have demonstrated superior efficacy in some models compared to PRP alone, particularly in promoting wound healing and reducing inflammation (Theranostics, 2017; Clinical and Experimental Medicine, 2025).
Benefits and Limitations of PRP and Exosome Therapies
Benefits
- Autologous and Biocompatible: PRP is derived from the patient’s own blood, reducing risk of allergic reactions.
- Minimally Invasive: Both treatments are non-surgical and performed in-office by certified providers.
- Regenerative Effects: Promote natural healing, collagen synthesis, and tissue repair.
- Versatility: Used for skin rejuvenation, scar revision, hair restoration, and adjunctive wound healing.
Limitations
- Standardization: Lack of standardized protocols for exosome isolation, dosing, and delivery.
- Evidence Base: Most data are from preclinical studies; large-scale clinical trials are limited.
- Variable Results: Individual outcomes may vary based on patient factors and treatment protocols.
- Regulatory Status: Exosome therapies are not FDA-approved for all indications; providers must follow current guidelines and best practices.
PRP and Exosomes vs. Other Skin Rejuvenation Methods
Patients often compare PRP/exosome therapies to established non-surgical skin rejuvenation options. Below is a factual comparison:
| Treatment | Mechanism | Invasiveness | Downtime | Evidence Base | Typical Uses | Key Limitations |
|---|---|---|---|---|---|---|
| PRP | Growth factor release | Low | Minimal | Moderate (growing) | Skin, hair, scars | Variable protocols, limited large trials |
| Exosomes | Cell signaling, repair | Low | Minimal | Early-stage (promising) | Skin, wounds, inflammation | Standardization, regulatory status |
| Microneedling | Collagen induction | Low | 1-3 days | Strong (many studies) | Texture, scars, fine lines | Mild discomfort, multiple sessions |
| Laser Skin Resurfacing | Controlled tissue ablation | Moderate | 3-10 days | Strong (FDA-cleared) | Wrinkles, pigmentation, scars | Redness, risk of pigment changes |
| Dermal Fillers | Volume restoration | Low | Minimal | Extensive (FDA-approved) | Wrinkles, volume loss, contouring | Temporary, rare risk of vascular events |
PRP and exosome therapies are unique in their regenerative approach, focusing on stimulating the body’s own repair mechanisms rather than simply filling or resurfacing tissue.
Why Choose Cosmetic Injectables Center Medspa for Regenerative Skin Treatments?
Cosmetic Injectables Center Medspa in Sherman Oaks is a physician-led practice specializing in advanced, non-surgical regenerative treatments. Under the full-time supervision of Dr. Sherly Soleiman, MD—a board-certified physician with over 25 years of experience and national faculty status for Allergan—patients receive care from certified expert injectors and licensed clinicians.
- Expertise: Dr. Soleiman is a recognized leader in non-surgical aesthetics, clinical research, and education (About Dr. Soleiman).
- Safety: All procedures are performed or supervised by credentialed professionals using evidence-based protocols.
- Comprehensive Services: In addition to PRP and exosome therapy, the practice offers microneedling, laser skin resurfacing, dermal fillers, and IV therapy.
- Patient-Centered Approach: Treatments are tailored to individual needs, with transparent discussion of benefits, risks, and alternatives.
Frequently Asked Questions
What is the difference between PRP and exosome therapy?
PRP uses a patient’s own platelets to deliver growth factors for tissue repair. Exosome therapy utilizes extracellular vesicles that act as biological messengers, enhancing cell communication and regeneration. PRP-derived exosomes may offer enhanced regenerative effects compared to PRP alone.
Are PRP and exosome treatments safe?
When performed by certified providers, PRP is considered safe due to its autologous nature. Exosome therapies are generally well-tolerated, but standardization and regulatory oversight are evolving. Individual results and risks may vary.
How many sessions are needed for optimal results?
The number of sessions depends on the indication, skin condition, and individual response. Most patients require a series of treatments for best results. Your provider will recommend a personalized plan.
What conditions can be treated with PRP and exosomes?
PRP and exosomes are used for skin rejuvenation, scar revision, hair restoration, and adjunctive wound healing. Emerging evidence supports their use in inflammatory and degenerative conditions, but not all applications are FDA-approved.
How do PRP and exosomes compare to microneedling or laser treatments?
PRP and exosomes focus on regeneration and healing, while microneedling and lasers primarily stimulate collagen through controlled injury or ablation. Combination approaches are sometimes used for enhanced results.
Is there any downtime after treatment?
Downtime is minimal for both PRP and exosome therapies. Some patients may experience mild redness or swelling, which typically resolves within 24-48 hours.
Are results permanent?
Results are not permanent, as aging and environmental factors continue to affect the skin. Maintenance treatments may be recommended.
Who is a good candidate for regenerative skin treatments?
Most healthy adults seeking non-surgical skin rejuvenation may be candidates. Contraindications include active infections, certain medical conditions, or pregnancy. A consultation with a certified provider is required.
Are PRP and exosome therapies FDA-approved?
PRP is FDA-cleared for certain orthopedic and dental uses; its use in aesthetics is considered off-label but widely practiced. Exosome therapies are not FDA-approved for aesthetic indications as of 2025; ongoing research may expand their approved uses.
How do I schedule a consultation?
Contact Cosmetic Injectables Center Medspa to schedule a complimentary consultation with a certified provider or a physician consultation with Dr. Sherly Soleiman, MD.
References:
- Exosomes derived from platelet-rich plasma alleviate synovial inflammation
- Macrophage membrane-encapsulated miRNA nanodelivery system
- PRP-derived exosomes accelerate healing of diabetic foot ulcers
- Therapeutic Potential of PRP-derived Exosomes: Literature Review
- Exosomes promote re-epithelization of chronic wounds
- Characterization and Therapeutic Use of Platelet-Derived EVs
- Advances in PRP-Derived EVs for Regenerative Medicine
For more information on regenerative skin treatments in Sherman Oaks, visit Cosmetic Injectables Center Medspa.