Jeuveau (prabotulinumtoxinA-xvfs) and Botox (onabotulinumtoxinA) are both FDA-approved neuromodulators for the temporary improvement of moderate to severe glabellar lines. While their mechanisms are similar, recent clinical research highlights distinct differences in onset, duration, and patient suitability. This article presents a comprehensive, evidence-based comparison to help patients and providers determine when Jeuveau may be the preferred choice. All procedures at Cosmetic Injectables Center Medspa are performed by certified expert injectors under the full-time, on-site supervision of Dr. Sherly Soleiman, MD, a nationally recognized leader in medical aesthetics.
Understanding Jeuveau and Botox: Mechanisms and Approvals
What Are Jeuveau and Botox?
Both Jeuveau and Botox are botulinum toxin type A neuromodulators that temporarily relax targeted facial muscles to reduce dynamic wrinkles, particularly glabellar lines (frown lines between the eyebrows).
- Jeuveau: FDA-approved in 2019 specifically for cosmetic use in glabellar lines.
- Botox: FDA-approved since 2002 for glabellar lines, with additional approvals for forehead lines, crow’s feet, and multiple medical indications (e.g., migraine, hyperhidrosis, TMJ).
Scientific Foundation and Clinical Trials
- Jeuveau’s pivotal Phase III trials (EV-001, EV-002) demonstrated responder rates of 67.5–70.4% for glabellar lines at Day 30, with a safety profile comparable to Botox (PMC6819028).
- Direct comparison trials confirm Jeuveau’s noninferiority to Botox in both efficacy and safety (Aesthetic Surgery Journal, 2020).
Jeuveau vs. Botox: Efficacy, Onset, and Duration
Efficacy
Both products deliver high efficacy in reducing glabellar lines, with similar responder rates in clinical trials.
- Jeuveau: 67–70% responder rate (≥2-point improvement) at Day 30
- Botox: 48–60% responder rate in historical trials
Onset of Action
- Jeuveau: Demonstrated a significantly faster onset of visible effect by Day 3 compared to Botox in a 2025 JAMA Dermatology study (JAMA Dermatology, 2025).
- Botox: Typical onset is 3–5 days, with peak effect at 2 weeks.
Duration of Results
- Jeuveau: Maintained significant effect at Day 180 (6 months) in recent studies, outperforming Botox at this time point in some trials.
- Botox: Duration typically 3–4 months for most patients, though individual results vary.
Safety Profile
Both products have comparable safety profiles, with low rates of adverse events such as headache and eyelid ptosis.
- Jeuveau: No new safety signals in recent FDA reviews (FDA 2025).
- Botox: Extensive safety data across cosmetic and medical uses.
Jeuveau vs. Botox: Comparison Table
| Feature | Jeuveau (prabotulinumtoxinA-xvfs) | Botox (onabotulinumtoxinA) |
|---|---|---|
| FDA Approval | 2019 (glabellar lines, cosmetic) | 2002 (glabellar lines, cosmetic); multiple medical uses |
| Primary Use | Cosmetic (glabellar lines) | Cosmetic & medical |
| Onset of Action | ~2–3 days (faster in some studies) | ~3–5 days |
| Duration | Up to 6 months in some studies | 3–4 months (typical) |
| Efficacy | Noninferior to Botox; 67–70% responder rate | 48–60% responder rate (historical) |
| Safety | Comparable to Botox | Extensive long-term data |
| Complexing Proteins | None (purified for cosmetic use) | Contains complexing proteins |
| Off-Label Use | Not indicated for medical conditions | Widely used for medical conditions |
| Patient Preference | May appeal to cosmetic-focused patients, those seeking faster onset or longer duration | Preferred for patients needing medical as well as cosmetic treatment |
| Gender Data | Higher responder rates in men (not statistically significant) | Effective in both genders |
Who Should Consider Jeuveau Over Botox?
Patients Seeking Faster Results
Clinical data show Jeuveau may produce visible improvements more quickly than Botox, making it a strong option for patients preparing for events or desiring rapid results (JAMA Dermatology, 2025).
Patients Prioritizing Cosmetic Use
Jeuveau is FDA-approved exclusively for cosmetic use and contains no complexing proteins, which may appeal to patients who want a product focused solely on aesthetics (FDA NDA 761085).
Men Seeking Glabellar Line Treatment
Post-hoc analyses indicate Jeuveau may offer higher responder rates in men compared to Botox, though differences are not statistically significant (Aesthetic Surgery Journal, 2022). Men seeking tailored cosmetic outcomes may consider Jeuveau as a first-line option.
Patients Interested in Longer Duration
Recent studies suggest Jeuveau’s effects may last up to 6 months for some patients, potentially reducing the frequency of treatments (JAMA Dermatology, 2025).
Patients Sensitive to Formulation Differences
Jeuveau’s purified formulation (lacking complexing proteins) may be preferable for patients who have experienced sensitivity or diminished response to other neuromodulators.
Patients Seeking a Modern Alternative
Some patients may prefer a newer product with recent regulatory scrutiny and a cosmetic-only profile, as highlighted in the 2025 FDA review (FDA 2025).
When Botox May Be Preferred
Patients Requiring Medical Indications
Botox is FDA-approved for a wide range of medical conditions (e.g., chronic migraine, hyperhidrosis, TMJ, spasticity). Patients seeking both cosmetic and medical benefits should consider Botox.
Patients with Established Treatment History
Patients who have achieved consistent, satisfactory results with Botox may prefer to continue with their established regimen, as individual response can vary.
Other Neuromodulator Options
Cosmetic Injectables Center Medspa also offers Dysport, Xeomin, and Daxxify, each with unique properties. Our certified expert injectors can help determine the best option based on your goals, anatomy, and medical history.
Why Choose Cosmetic Injectables Center Medspa for Neuromodulators?
All neuromodulator treatments at Cosmetic Injectables Center Medspa are performed by certified expert injectors under the direct, on-site supervision of Dr. Sherly Soleiman, MD, a board-certified physician and national trainer for leading brands. Our team prioritizes safety, natural results, and patient education, ensuring every treatment is tailored to your unique needs.
“My favorite procedure is doing what makes the face look natural… Injectables are a wonderful tool to enhance a person’s confidence, but the result has the opposite effect if they look awkward and out of proportion.” – Dr. Soleiman, Beverly Hills Magazine
Frequently Asked Questions
Is Jeuveau as effective as Botox for glabellar lines?
How quickly will I see results with Jeuveau?
How long do Jeuveau results last compared to Botox?
Is Jeuveau safer than Botox?
Can Jeuveau be used for medical conditions like migraines?
Who is the best candidate for Jeuveau?
Are there differences in dosing between Jeuveau and Botox?
Can men benefit from Jeuveau?
What are the most common side effects of Jeuveau?
How do I choose between Jeuveau, Botox, and other neuromodulators?
For more information or to schedule a consultation with a certified expert injector at Cosmetic Injectables Center Medspa, visit our Wrinkle Relaxers page or contact us directly. All procedures are performed under the direct supervision of Dr. Sherly Soleiman, MD, ensuring the highest standards of safety and natural results.